Engineering delivery platforms for controlled nitric oxide release

-protected diazeniumdiolates, protected SIN-1, nitrobenzene derivatives, BNN6). Here, we highlight recent advances in the engineering of delivery platforms, including polymeric nanoparticles, hydrogels, xerogels, liposomes, and various inorganic materials, which enable precise, stimuli-triggered NO release, improved stability, and tissue-specific targeting. By integrating NO donor chemistry with materials design, these platforms offer strong potential for controlled NO-based therapies across a wide range of biomedical applications. We conclude by outlining future directions and key challenges in translating NO delivery systems into clinically viable therapeutics.