Dandan Zhu, Huiling Zhu, Yaoyun Yu, Junyue Zheng, Xianhui Lin, Huimin Cheng, Aoxue Mei, Ming Chen, Yun Li, Haijuan Dong, Jiehua Zhou, Juan LIU, Xiaoxuan Liu
achieved substantial reductions in tumor growth and PLK1 expression while exhibiting minimal systemic toxicity. This study highlights a synergistic approach utilizing bola-amphiphilic peptide dendrimers for tumor-specific and cytosolic siRNA delivery, leveraging membrane-thiol interactions and intracellular GSH-triggered siRNA release.