Jia Ke, Jing Ding, Yichong Xu, Caini Yu, Yiling Hong, Sufen Li, Tingting Meng, Ping Yuan, Hong Yuan, Fuqiang Hu
results demonstrated that Exo-124-3p significantly improved the cognitive function in an AD mouse model. Mechanistically, it was elucidated that Exo-124-3p can bind to the 3'UTR region of MEKK3, ultimately inhibiting the MEKK3/NF-κB signaling pathway, thereby ameliorating AD neuroinflammation. Consequently, this study not only provides a promising therapeutic approach for AD combinational therapy, but also advances the development of miRNA delivery in other brain diseases.