Ethyl gallate as an unexplored organocatalyst: unlocking sustainable routes to isoxazolones.

A simple and effective approach has been established for producing a wide range of pharmaceutically valuable functionalised 3-methyl-4-(hetero)arylmethylene isoxazole-5(4H)-ones. In this method, ethyl gallate (EG) was identified as a previously unexplored and potent organocatalyst, allowing for quick one-pot conversion to isoxazolones. The technique offers several major benefits, including metal-free conditions, good to exceptional yields, the use of readily available starting materials, and overall operational simplicity.