Zhuanhuai Wang, Hengjun Huang, Hui Li
Heterogeneous nuclear ribonucleoprotein F (hnRNP F), a member of the hnRNP family, is an essential regulator of RNA metabolism, influencing splicing, translation, stability, and telomere maintenance. This review provides a comprehensive overview of the regulation of expression and multifunctional roles of hnRNP F. Owing to the high degree of sequence homology and functional similarity between hnRNP F and hnRNP H/H', this review also integrates discussions on hnRNP H/H' to facilitate a comparative and holistic understanding of their biological significance.