The brain side of human-AI interactions in the long-term: the “3R principle”

Neuroplasticity is shaped by how humans interact with AI. We argue that passive, uncritical, reliance on AI may weaken activity-dependent brain plasticity and erode cognition, whereas active co-creation can sustain or enhance it. Drawing on plasticity rules and ethical considerations, we propose the 3R principle—Results, Responses, Responsibility—as a preventive framework for cognitive hygiene, urging education towards AI use to preserve agency, meaning-making, and long-term brain health.