Ivet A. Yordanova, Joseph Prescott
Marburg virus (MARV) is a highly pathogenic zoonotic filovirus. The Orthomarburgvirus marburgense species includes MARV and Ravn virus (RAVV), which differs from MARV by 21% at the nucleotide level and 22% at the protein level. This review offers fresh discussions of the epidemiology, genetics and natural reservoir transmission of RAVV, summarizes experimental animal models, outlines current vaccine development and raises outstanding questions about RAVV life history, transmission and pathogenicity.