Modelling drug-induced cellular perturbation responses with a biologically informed dual-branch transformer
Yue Guo, Hao Zhang, Haitao Hu, Jialu Wu, Ji Cao, Chang-Yu Hsieh, Bo Yang
原始摘要（英文原文）· Original abstract
A dual-branch framework that disentangles cell states from drug-induced regulatory shifts to predict transcriptional responses is presented. It captures nonlinear dose–time dynamics and excels in generalizing to unseen cellular contexts.