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◆ Communications Chemistry2026-06-02· Silylation

Unlocking Lewis acid–free metalation of O–nucleophiles in HFIP

Kacper Łyczek, Martyna Markwitz, Maciej Janicki, Krzysztof Kuciński

原始摘要(英文原文)· Original abstract
Allylsilanes are primarily used in allylation reactions that form new C-C bonds. Although they can also serve as silylating reagents to generate Si-O bonds, such transformations have generally required Brønsted or Lewis acid catalysis. Herein, we describe an acid-free method to access silyl ethers, siloxanes, and borasiloxanes via silylation or borylation. Hexafluoroisopropanol enables this reactivity, allowing a wide range of alcohols and silanols to undergo efficient conversion under mild conditions.
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Unlocking Lewis acid–free metalation of O–nucleophiles in HFIP — 科研速览 Science Skim