Damian M. Bailey, Dieter Blottner, Hanns‐Christian Gunga, Stefan Schneider, Virginia E. Wotring, Sarah Baatout, Marco Durante, Rik Olde Engberink, Nandu Goswami, Martina Heer, Anna‐Maria Liphardt, Monica Monici, Francesco Pagnini, Claudia Stern, Jan‐Bernd Stukenborg, Tobias Weber, Laurence Vico, Olivier White, Angelique Van Ombergen, Alexander Choukèr
Human spaceflight is advancing toward sustainable exploration through initiatives like NASA's Artemis program, aiming for a lunar outpost and eventual Mars mission. Astronauts face hazards including altered gravity, isolation, and cosmic radiation, linked to over thirty health risks. This review, reflecting ESA community expertise, outlines how understanding the space exposome-integrome interaction can improve risk stratification, guide personalized countermeasures, and address knowledge gaps essential for safe deep-space exploration.