Pawel Kordowitzki, Kejun Ying
Precise recommendations for humans to reach more than 100 years remain elusive. A recent multiomics study revealed that extreme age and poor health are not inherently linked. Longevity stems from a multifactorial resilience that involves protective genetics, efficient metabolism, low inflammation, and favorable lifestyle choices. Insights from centenarians and Blue Zones suggest that healthy aging is rooted in the synergistic interplay of biological, environmental, and above mentioned factors.