Nickel-catalyzed ring-opening difunctionalization of methylenecyclobutanes via strain-release-enabled C-C activation

The efficient construction of molecular complexity from simple building blocks is a significant goal in catalysis, and the controlled ring-opening functionalization of strained carbocycles provides a powerful strategy to achieve it. However, selective catalytic strategies for ring-opening difunctionalization of methylenecyclobutanes (MCBs) remain elusive. Here, we report a nickel-catalyzed method that enables the 1,4-dicarbofunctionalization and 1,4-hydrocarbofunctionalization of MCBs via selective C–C bond cleavage. This protocol exploits the strain energy and dual reactivity of MCBs to deliver nonadjacent C(sp3)/C(sp2) frameworks in good to excellent yields under mild conditions. A broad substrate scope, scalability to the gram scale, and versatile downstream transformations demonstrate the synthetic utility of this approach. Mechanistic studies, including control, isotope-labeling experiments, and DFT calculations, reveal a distinct cooperative pathway involving strain-driven β-carbon elimination, offering new opportunities for catalyst-controlled activation of MCBs. Selective catalytic strategies for ring-opening difunctionalization of methylenecyclobutanes (MCBs) remain elusive. Here, the authors report a nickel-catalyzed method that enables the 1,4- dicarbofunctionalization and 1,4- hydrocarbofunctionalization of MCBs.