Sen Gao, Shishang Qin, Dongfang Wang, Anqiang Wang, Linnan Zhu, Yang Li, Qiang Shi, Hongtao Fan, Yufei Bo, Yunshan Zhong, Yuxuan Sun, Kun Dong, Liqin Fu, Ranran Gao, Yan Wu, Ye Liang, Luyujie Huang, Xueda Hu, Xianwen Ren, Zhaode Bu, Jiafu Ji, Zemin Zhang
The spatial organisation of the tumour microenvironment (TME) can affect immune responses that control tumour growth. Here, the authors use single-cell transcriptomics and spatial transcriptomics to identify a lymphocyte aggregated region (LAR) in gastric cancer and compare its cellular and molecular composition with the neighbouring TME.