Natalia Truong-Andrievici, Jean−Fred Fontaine, Sebastian Kunz, Barbara Cipriani, Miguel A. Andrade-Navarro, Toszka Bohn, Tobias Bopp
Aggressively growing tumors preferentially rely on anaerobic glycolysis for energy production, resulting in acidification of the tumor microenvironment (TME). Tumor acidosis not only alters the tumor-stroma structure, enhancing invasiveness, 1 but also affects tumor-infiltrating immune cells, such as tumor-associated macrophages (TAM), by promoting a tumor progressive anti-inflammatory polarization. 2 The cellular composition of the TME plays a crucial role for the prognosis of cancer patients and can significantly influence the clinical efficacy of various treatment modalities. 3 Therefore, we sought to understand the molecular basis of acidosis-evoked immune evasion by strongly acidifying tumors.