Hanqin Zhao, Yuxi Gao, Yibo Qi, An Ziyue, Minhui Li, Jie Chen, Sheng Ma, Wantong Song, Xuesi Chen
profiles, which in turn adsorb plasma protein coronas forming specific "protein fingerprints" that mediate organ-selective capability. The MACO mechanism represents the demonstration of organ-selective mRNA delivery governed solely by formulation parameters rather than polyplex structural alterations, providing a universal strategy to finely tune the mRNA multiorgan target.