Double Deoxygenative Coupling of Carboxylic Acids and Alcohols

High Resolution Image Download MS PowerPoint Slide Ketones are highly valued for their versatility in functional group interconversions and prevalence in bioactive molecules. However, the synthesis of complex ketones often requires organometallic reagents or prefunctionalized substrates. Herein, we report a photoredox-catalyzed double deoxygenative fragment coupling between alcohols and carboxylic acids to access diverse, sp 3 -rich ketone scaffolds. This transformation proceeds under mild conditions and leverages abundant starting materials. We further expand the logic of radical cross-coupling via a bis-radical SOMO stitching approach that unites two alcohol-derived fragments to forge C 1 -connected ketone products.