Energy Transfer Photocatalytic Carboamination of Alkenes toward Primary Amine-Derivatized Trifluoromethyl Ketals.

Direct carboamination of alkenes to access structurally complex fluorinated amines remains challenging, particularly when simultaneously installing a trifluoromethyl ketone and a primary amine. With a bifunctional reagent that combines a trifluoromethyl ketal and an imine functionality, we established a metal-free photocatalytic energy-transfer (EnT) strategy for the bifunctionalization of alkenes. Using thioxanthone as the photocatalyst, the reaction accommodates diverse alkene substrates and applies to continuous-flow synthesis.