Yan-Jiang Zhang, Lu Gan, Yi-Ling Liao, Long Jiang, Dai-Lin Tang, Wei Liu, Sheng Yin, Gui-Hua Tang
Two unprecedented azaphilone hybrids─chaeglobocinnin A ( 1 ) and chaeglobokojin A ( 2 )─featuring chaetoviridin-type cores coupled with cinnamic acid and kojic acid, respectively, were isolated from an endophytic fungus Chaetomium globosum .
Two unprecedented azaphilone hybrids─chaeglobocinnin A ( 1 ) and chaeglobokojin A ( 2 )─featuring chaetoviridin-type cores coupled with cinnamic acid and kojic acid, respectively, were isolated from an endophytic fungus Chaetomium globosum . 1 features a 6/6/6/6 fused tetracyclic framework with a benzene ring attached as a pendant moiety. 2 possesses an unprecedented 6/6/5/6/6 pentacyclic system characterized by a spiro moiety. Their structures were unequivocally established by comprehensive spectroscopic analysis, NMR calculations with DP4+ probability analysis, and single-crystal X-ray diffraction. Additionally, 2 exhibited antiliver fibrosis activity via inhibition of the TGF-β/Smad signaling pathway.