Modular Synthesis of Chiral Tetrasubstituted Allylic Amines via Nickel-Catalyzed Enantioselective Difunctionalization of Alkynes with Imines and Arylboronic Acids

Difunctionalization of internal alkynes provides prominent methods for the modular construction of tetrasubstituted alkenes. However, the development of an enantioselective version of such transformation remains elusive. We present herein an enantioselective nickel-catalyzed arylative coupling reaction of simple alkynes with N -sulfonylimines and arylboronic reagents. This asymmetric three-component transformation furnished a wide range of enantioenriched tetrasubstituted allylic amines with excellent regioselectivity and stereoselectivity under mild conditions.