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◆ Organic Letters2026-03-26· Chemistry

Visible-Light Induced Dehydrogenative Cross-Coupling of Enamides with Hydrocarbons Enabled by Aryl Thianthrenium Salt

Jian Han, Qiu-Ru Zhang, Yi-Lin Wang, Xiao-ya LU, Li-Li Zeng, Yali Li, Fen-Er Chen

原始摘要(英文原文)· Original abstract
)-H alkylation of enamides with easily accessible hydrocarbons under mild conditions. The utilization of aryl thianthrenium salt as a hydrogen-atom transfer (HAT) precursor enables the smooth generation of diverse carbon-centered radicals from chemical feedstocks containing hydridic or protic C-H bonds. Noteworthy features of this protocol encompass high step efficiency, good functional group compatibility, and excellent chemo-, regio-, and stereoselectivity. Mechanistic experiments and density functional theory (DFT) calculations support the involvement of an electron donor-acceptor (EDA) complex.
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Visible-Light Induced Dehydrogenative Cross-Coupling of Enamides with Hydrocarbons Enabled by Aryl Thianthrenium Salt — 科研速览 Science Skim