Zhetong Liu, Tao Yang, Xiaozhi Huang, Qing Rong Qi, Chending Luo, Nan Wang, Yujiao Shu, Haitian Zhang, Guanqun Zhan, Zengjun Guo
Spiropenicitrinol A ( 1 ), an intriguing 5/5/6/5 spirocyclic polyketide architecture with a unique 3 H -spiro[benzo[1,2- b:4,5- b ′]difuran-2,1′-cyclopentane] core, was obtained from Penicillium citrinum Y12. The structure was established by spectroscopic analysis, quantum-chemical calculations, and single-crystal X-ray crystallography. 1 showed potent anti-inflammatory activity by inhibiting LPS-induced NO, TNF-α, IL-6, and IL-1β production in RAW264.7 cells. These findings indicated that this complex spirocyclic architecture could serve as a promising scaffold for the further development of novel anti-inflammatory agents.