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◆ Organic Letters2026-01-07· Chemistry

Difluoromethylation of Arylsulfonium Salts with TMSCF <sub>2</sub> H

Jun Yang, Jia-Wei Song, Cheng‐Pan Zhang

原始摘要(英文原文)· Original abstract
H in DMF in the presence of CsF is achieved. The reaction proceeded smoothly at room temperature to furnish the corresponding difluoromethylated products in good yield with excellent selectivity through the formation and ligand coupling of sulfurane intermediates. This protocol represents the first catalyst-free difluoromethylation of arylsulfonium salts, exhibiting features distinct from those of previously reported metallophotocatalytic fluoroalkylation.
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Difluoromethylation of Arylsulfonium Salts with TMSCF <sub>2</sub> H — 科研速览 Science Skim