Xinyue Wang, Chun Ma, Junfeng Yang, Junliang Zhang
N, O -Spirocycles are important structural motifs in efficient chiral ligands, natural products, and pharmaceuticals. However, the achievement of highly enantioselective N, O -spirocycles remains a challenge. Herein, we present a Pd-catalyzed enantioselective dearomatization of bromofurans with N -tosylhydrazones using a newly developed chiral sulfinamide phosphine ligand. The reaction features an excellent Z/E ratio, high enantioselectivity, and mild reaction conditions. The synthetic versatility of N, O -spirocycles is demonstrated.