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◆ Organic Letters2025-12-18· Chemistry

Ph <sub>3</sub> N as an Organocatalytic Donor for Photoactivation of Pyridinium-Masked Enols in the Formal [4 + 2] Cycloaddition with Unactivated Olefins

Jin Li, Z. Ji, Haiming Wang, Xiaoping Hu, Xiaohan Lu, Tanyu Cheng, Guohua Liu, Rui Liu

原始摘要(英文原文)· Original abstract
Herein, we demonstrated that commercially available and inexpensive triphenylamine (NPh 3 ) could act as an electron donor to form electron donor–acceptor (EDA) complexes with pyridinium-masked enols. Upon irradiation with blue light (455 nm), this in situ formed EDA complex was activated to provide the α-carbonyl radical through N–O bond cleavage, serving as the radical precursor in the formal [4 + 2] cycloaddition with unactivated olefins. A series of pyridinium-masked enols and functionalized olefins were examined under optimized conditions. Mechanistic studies revealed that α-carbon radical and γ-carbonyl radical intermediates are involved during this catalytic process.
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Ph <sub>3</sub> N as an Organocatalytic Donor for Photoactivation of Pyridinium-Masked Enols in the Formal [4 + 2] Cycloaddition with Unactivated Olefins — 科研速览 Science Skim