Copper-Catalyzed Domino Reaction of Arylidene Isoxazolones with 2-(Pyridin-2-yl)acetate Derivatives under Ball Milling: A Rapid and Economical Synthesis of 3-Acylindolizines

A copper-catalyzed domino reaction of arylidene isoxazolones with 2-(pyridin-2-yl)acetate derivatives under ball-milling conditions has been developed. This protocol provides a rapid and economic approach to constructing a vast variety of biologically important 3-acylindolizines with remarkable functional group tolerance.