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◆ Organic Letters2026-01-19· Chemistry

Temperature Dependent Divergent Radical Oxidative Amidation Engaging Arylglyoxyl Radicals

Pratibha Bhatti, Anjali Gupta, Shubham Chaudhari, Joydev K. Laha

原始摘要(英文原文)· Original abstract
The present study reports the divergent reaction of previously underexplored arylglyoxyl radicals generated in situ from arylglyoxals in the presence of tert -butyl hydroperoxide (TBHP) and a catalytic amount of iodine with various amines at two different temperatures leading to the synthesis of arylglyoxal amides at 120 °C and aromatic amides at 180 °C. The two radicals, arylglyoxyl radical and aroyl radical, generated via decarbonylation at higher temperature, could react with amines via radical polar crossover.
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