Younis Rasool, Yashika Sharma, Bhupesh Sharma, Ravi Shankar
Herein, we report a practical and efficient carbon-to-nitrogen atom swap in 2-phenylimidazo[2,1- a ]isoquinoline and 2-phenylimidazo[1,2- a ]quinoline scaffolds, enabling their direct conversion to the corresponding 2-phenyl-[1,2,4]triazolo[5,1- a ]isoquinoline and 2-phenyl-[1,2,4]triazolo[1,5- a ]quinoline analogues. This transformation exploits the intrinsic reactivity of the parent heterocycles to undergo a cascade sequence involving oxidative cleavage, amination, and cyclization (OCAC) under mild conditions with functional group tolerance.