Zhenqi Wang, Yanjie Yang, Xing-Bang Liu, Siyu Wan, Pin Gao, Yuan Huang
Herein, we report a practical nickel-catalyzed reductive cross-coupling of α-chloro- gem -diboron compounds with carbon electrophiles, providing efficient access to a broad range of gem -diboron structures, including previously underdeveloped α-arylated derivatives. This transformation proceeds via an underdeveloped gem -diboron radical intermediate pathway and features mild conditions, operational simplicity, excellent regioselectivity, and broad functional group tolerance. Notably, this method overcomes the long-standing challenge of Csp 3 –Csp 3 bond formation using simple alkyl halide electrophiles, thereby expanding access to traditionally elusive molecular scaffolds.