A Three-Dimensional MOF Electrochemical Sensor Based on Zn4O(BDC)3/Acetylene Black for Sensitive Rapid Detection of Fluazinam Residues in Foods.

Fluazinam is a benzamide fungicide commonly used in agricultural production to prevent and control fungal-induced plant diseases. However, its residues in food products can pose potential health hazards. To address this issue, we have developed an electrochemical sensor based on a MOF-5/AB-modified glassy carbon electrode (GCE) for sensitive detection of fluazinam. In this work, a high-performance electrochemical sensor was fabricated via a simple composite strategy by combining AB, which possesses high electrical conductivity and superior electron transfer ability, with MOF-5, a material featuring a well-developed porous structure and large specific surface area. The structural and morphological characteristics of the MOF-5/AB and electrochemical sensing performance toward fluazinam of MOF-5/AB/GCE are investigated. The MOF-5/AB/GCE exhibited outstanding electrochemical sensing performance for fluazinam detection, providing an ultralow detection limit of 0.0166 μM, a wide linear range of 0-100 μM, high sensitivity, excellent reproducibility and stability, and remarkable selectivity against common interfering species. In real samples, fluazinam yielded high recovery rates, confirming the potential of MOF-5/AB/GCE for practical environmental and biomedical monitoring applications. This research provides a novel and efficient sensing platform for electrochemical detection of fluazinam residues and offers a valuable reference for modification of MOFs and their extended applications in the field of electrochemical sensing.