Sheema Jan, Javeed Ahmad Sheikh, Kowsar Majid
There is a high risk of heavy metal contamination to both the environment and the population; hence, special care and selective, trustworthy detection technology is required. This paper describes the preparation and use of a CoFe 2 O 4 @Fe-Pda metal–organic framework (MOF)-based electrochemical sensor to concurrently detect Cd 2+, Cu 2+, and Hg 2+ ions. The sensor exhibits a strong electrochemical response, characterized by well-resolved peak potentials for each target ion and a linear current response as the target ion concentration varies. Measurement of differential pulse voltammetry (DPV) provides a limit of detection (LOD) of 9.6 ppb Cd 2+ (10–55 ppb), 13.5 ppb Cu 2+ (5–55 ppb) and 12.0 ppb Hg 2+ (3–55 ppb) in individual analysis and 15 ppb, 8.45 ppb, and 11 ppb for simultaneous detection of Cd 2+, Cu 2+, and Hg 2+ ions, respectively. It is interesting to note that the presence of one metal ion does not affect the detection of the others, even at lower concentrations, which supports the sensor’s high selectivity and minimal cross-reactivity. The increased sensing power can be ascribed to the synergistic effects between the magnetic CoFe 2 O 4 nanoparticles and the Fe-Pda MOF, which together enable rapid electron transfer, a high surface area, and the potential for specific molecular interactions. These results demonstrate the promise of the CoFe 2 O 4 @Fe-Pda MOF as a robust electrochemical sensing platform for tracking toxic heavy metals in real time under complex aqueous conditions.