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◆ The Journal of organic chemistry2026-09-11

Divergent [3 + 2] and [4 + 2] Annulation of O-Tosylhydroxylamines: Assembly of Amino-Substituted Tetrahydrofuran and Oxazinane Spirooxindoles.

Jiaxu Feng, Lulu Xu, Zichen Zhang, Yingying Wu, Qinpeng Li, Zhi Fan

原始摘要(英文原文)· Original abstract
The Cs2CO3-mediated divergent [3 + 2] and [4 + 2] annulation of O-tosylhydroxylamines with 3-hydroxyoxindole has been disclosed, delivering various amino-substituted tetrahydrofuran and oxazinane spirooxindoles in moderate to good yields. The diastereoselective [3 + 2] annulation approach exhibits mild conditions and good substrate tolerance.
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Divergent [3 + 2] and [4 + 2] Annulation of O-Tosylhydroxylamines: Assembly of Amino-Substituted Tetrahydrofuran and Oxazinane Spirooxindoles. — 科研速览 Science Skim