Baran Ozveren, Antoine Coeuillas, Philippe Jubault, Laëtitia Chausset-Boissarie, Thomas Poisson, Julien Legros
Herein, we disclose a continuous-flow protocol for the lithiation of thiazoles, followed by a halogen dance rearrangement and subsequent trapping with diverse electrophiles. The transformation proceeds rapidly, occurring in less than 1 min, and exhibits broad applicability across a range of substrates, including oxazole and imidazole derivatives. The implementation of continuous-flow conditions provides enhanced control over reaction parameters and enables facile scale-up, thereby offering significant advantages for the development of streamlined and scalable synthetic methodologies.