Yangjian Cheng, Guocheng Yin, Jin-Tao Yu
-arylmethacrylohydrazides and hydroxamic acid derivatives for the synthesis of pyrazol-5-ones via 1,5-hydrogen atom transfer was developed.
-arylmethacrylohydrazides and hydroxamic acid derivatives for the synthesis of pyrazol-5-ones via 1,5-hydrogen atom transfer was developed. A series of pyrazol-5-ones was obtained in good yield with a broad substrate scope and excellent functional group compatibility. The procedure was also applied to the late-stage modification of natural products and drug molecules.