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◆ Journal of Medicinal Chemistry2026-05-02· Prodrug

A Near-Infrared Photoactivatable, Brain-Penetrant Prodrug of the Prolyl Hydroxylase Inhibitor Vadadustat for Neuroprotection in Ischemic Stroke

Ke Li, Tiande Bing, Yikai Mo, Wenxuan Wang, Jihong Xing, Le Yang, Danni Ao, Zhihong Li, Fulai Yang, Yue Wu, Xiaojin Zhang

原始摘要(英文原文)· Original abstract
reduced infarct volume and brain edema, and promoted neurological recovery. These findings highlight a photoactivatable, brain-penetrant prodrug strategy for spatiotemporally controlled neuroprotection.
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A Near-Infrared Photoactivatable, Brain-Penetrant Prodrug of the Prolyl Hydroxylase Inhibitor Vadadustat for Neuroprotection in Ischemic Stroke — 科研速览 Science Skim