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◆ Chemistry & biodiversity2026-09-01

Five New Iridoids From the Leaves of Viburnum macrocephalum f. macrocephalum and Their Free Radical Scavenging Activity.

Ya-Jiao Chen, Hong-Juan Zhou, Jia Chen, Jian-Hua Shao, Chun-Chao Zhao

原始摘要(英文原文)· Original abstract
An investigation of the chemical constituents of Viburnum macrocephalum f. macrocephalum leaves (VMML) resulted in the purification of five previously unreported iridoids, viburetins D-H (1-5), along with one known analogue (6). Compounds 1-5 were identified by combined spectroscopic and spectrometric techniques, including 1D/2D NMR, HRESIMS, and ECD. Antioxidant assays revealed that compounds 2, 5, and 6 exhibited DPPH (IC50: 36.58-53.90 µM) and ABTS (IC50: 25.96-45.80 µM) free radical scavenging activity, whereas compound 1 was appreciably active in the ABTS assay (IC50 = 58.47 µM). Notably, compound 6 was the most potent antioxidant, showing greater activity than the positive control Trolox in both assays (DPPH: IC50 = 36.58 vs. 41.12 µM; ABTS: IC50 = 25.96 vs. 29.09 µM). These findings have enriched the chemical diversity of iridoids from VMML and provided preliminary evidence for their free radical scavenging activity.
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Five New Iridoids From the Leaves of Viburnum macrocephalum f. macrocephalum and Their Free Radical Scavenging Activity. — 科研速览 Science Skim