Daniela Berardinelli, Carmen Fava, Valentina Bonuomo, Selene Grano, Federica Sinisi, Inga Ventimiglia, Graziella Costamagna, Paola Di Giulio, Sara Campagna, Andrea Ricotti, Valerio Dimonte
An approximate model-based component of the ADHD-NSCLC genetic covariance was statistically independent of the measured current-smoking phenotype; pathway and biomarker analyses suggested, but did not establish, an innate immune and inflammatory dimension alongside the 15q25 cholinergic axis. CLPTM1L expression was responsive in a non-nicotine pathological cell state, without evidence of mediation or causality. These hypothesis-generating findings nominate innate-immune hypotheses for functional follow-up.
AIM: To investigate the symptom burden associated with MPNs and its impact on patients' psychophysical well-being and quality of life through a structured PROM-based nurse-led visit.
DESIGN: Observational study.
METHODS: We included MPN patients followed at the haematology outpatient clinic of a large university-affiliated hospital in Italy. Data were collected from September 2024 to March 2025 on 102 patients who underwent a structured PROM-based nurse-led visit supported by a dedicated symptom diary.
RESULTS: Symptom burden was substantial (85% were symptomatic) across all disease subtypes, with fatigue emerging as the most prominent symptom, affecting 72% of patients and accompanied by marked psychological distress (42% and 44% with anxious and depressive symptoms, respectively). Overall health-related quality of life was predominantly moderate (mean score: 70.7 ± 21.3). Nearly all moderate-to-severe symptoms, including fatigue, inactivity, pain, itching, and abdominal discomfort, were strongly associated with impaired global health. 43% of patients need support in becoming more proactive in managing their disease, and satisfaction with the visit was very high (mean score 9.3 ± 1.3/10).
CONCLUSION: The impact of MPNs was significant and multifaceted, affecting patients' physical, emotional, and social well-being. Structured PROM-based nurse-led visits play a key role in detecting patients' needs and supporting symptom management across all domains of well-being, fostering motivated engagement.
IMPLICATIONS FOR THE PROFESSION AND PATIENT CARE: Integrating structured PROM-based nurse-led visits into routine haematology care may improve symptom monitoring, support patient engagement, and guide timely and tailored supportive interventions.
IMPACT: Patients with MPNs experience a substantial physical and psychosocial symptom burden. Symptom clusters are associated with anxiety, depression, and reduced quality of life. Structured PROM-based nurse-led visits may facilitate the early identification of unmet supportive care needs.
REPORTING METHOD: Guidelines for reporting observational studies (STROBE): PATIENT CONTRIBUTION: Patients actively participated during the nurse-led visit and in data collection.