Behavior change, health, and health disparities 2025: Intersections of tobacco use with other addictions, chronic disease, and health disparities.

This Special Issue (SI) of Preventive Medicine is the 12th in an annual series on behavior change, health, and health disparities. The theme of this 2025 issue is Intersections of Tobacco Use with Other Addictions, Chronic Disease, and Health Disparities. Considerable attention is given to cigarette smoking as it remains the leading cause of preventable death in the U.S., causing approximately 450,000 deaths annually in the U.S. and more than 7 million globally. This SI includes thirteen peer-reviewed articles that were invited from speakers at the 2024 annual conference of the Vermont Center on Behavior and Health. These articles report results from epidemiological studies, clinical trials, and commentaries. Collectively, the articles advance knowledge across a wide range of topics regarding the disproportionate impact of smoking and other tobacco use in vulnerable populations, intersections with other addictions, chronic disease, and health disparities along with clinical and regulatory interventions to reduce use and associated adverse health effects.