Tommaso Bertoni, Giulia Ricci, Jane Jöhr, Brunella Donno, Jacinthe Cataldi, Julia Fellrath, Aurélie Stephan, Carolina Foglia, Sandro Lecci, Floriane Dauvin, Marina Lopes da Silva, Mattia Galigani, Polona Pozeg, Vincent Dunet, Marzia De Lucia, Jean-Paul Noel, Elisa Magosso, Karin Diserens, Francesca Siclari, Andrea Serino
Reliably detecting consciousness in unresponsive patients remains an urgent ethical and clinical challenge, as no behavior-independent marker is currently accepted in clinical practice. We characterize consciousness as linked to a representation of the embodied subject of experience, mediated by multisensory integration within the peripersonal space (PPS) system. We test whether a neural marker of PPS representation could detect consciousness and predict clinical outcome in disorders of consciousness (DoC) patients. Using high-density electroencephalography (EEG) during a task-free audiotactile task, we derive a PPS index based on high-beta oscillations. In healthy participants, the PPS index is present during wakefulness and dreaming, but absent in dreamless sleep. In 72 DoC patients, the PPS index correlates with behavioral measures of consciousness and predicts recovery at discharge. The index is associated with forebrain mesocircuit integrity. These findings highlight a bedside-compatible electrophysiological marker with potential clinical utility for detecting covert consciousness and predicting outcomes in non-responsive patients.