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◆ Cell Reports Medicine2026-01-21· Conjugate

Design of a bispecific peptide-nanozyme conjugate for cancer immunotherapy

Danhong Chen, Ran Xu, Xiaoyun Ye, Youmei Xiao, Mengfan Wang, Wanqiong Li, Feiyu Luo, Xiaoshuang Niu, Xia Yang, Ye Su, Wenxuan Zeng, Ying Liu, Wenzhi Shang, Yang Li, Xin Zhao, J Hu, Xiaoshuang Chen, Xueqin Zhu, Xinghua Sui, Yanfeng Gao

原始摘要(英文原文)· Original abstract
T cell infiltration and activation in anti-PD-1-resistant tumor model. The BsPNEC platform integrates tumor-targeted delivery, magnetic resonance imaging (MRI) contrast capabilities, and robust inhibition of tumor growth. Our findings present a synergistic immunotherapeutic strategy that simultaneously skews immunosuppressive TME and amplifies T cell immune response.
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