A review of the parasiticidal efficacy of a selamectin plus sarolaner combination for use on cats.

The topical combination of selamectin and sarolaner (Stronghold® Plus in the European Union and Revolution® Plus in global regions) is a low-volume, spot-on parasiticide for monthly administration on cats providing a minimum dose of 6.0 mg/kg selamectin and 1.0 mg/kg sarolaner. The combination of two active ingredients with efficacy against fleas (Ctenocephalides felis) but with different modes of action works in synchrony to provide both high efficacy and fast speed of kill against fleas, resulting in an inhibited flea egg production,reduced flea allergic dermatitis and risk of infection with Dipylidium caninum. Broad-spectrum efficacy against 10 tick species has been demonstrated with efficacy exceeding 90% for at least four weeks after a single treatment against Amblyomma americanum, Amblyomma maculatum, Dermacentor reticulatus, Dermacentor variabilis, Haemaphysalis longicornis, Ixodes hexagonus, Ixodes holocyclus, Ixodes ricinus, Ixodes scapularis, and Rhipicephalus sanguineus. The rapid speed of kill reduces the likelihood of transmission of tick-borne pathogens such as Borrelia burgdorferi, Anaplasma phagocytophilum and Cytauxzoon felis. Single-dose studies targeting mites demonstrated high efficacy against Otodectes cynotis, and complete elimination of Notoedres cati within 30 days. Infestations with Demodex spp. have been successfully treated with single or multiple applications. Next to its efficacy against a broad range of ectoparasites, the well-known efficacy of selamectin against Toxocara cati, Ancylostoma tubaeformae and Dirofilaria immitis was confirmed in laboratory studies and field studies. The selamectin and sarolaner combination thus targets a broad spectrum of parasites, providing comprehensive parasite control.