Deubiquitinase inhibition exposes a subtype-specific vulnerability in SCLC-P.

In a recent study published in Cell Press Blue, Huang et al. show that deubiquitinase-dependent stabilization of POU2F3 (POU class 2 homeobox 3), primarily driven by USP2 (Ubiquitin-Specific Protease 2), sustains the growth of the small cell lung cancer (SCLC)-P subtype of SCLC, revealing a strategy to exploit transcription factor dependence by disrupting protein stability.