Evangelia Stampolaki, Alice Mondello, Eugenio Alladio, Paolo Oliveri, Alberto Mazzoleni, Francisco Pena‐Pereira, Elefteria Psillakis
GreenSOL is the first comprehensive solvent selection guide tailored specifically to analytical chemistry. It employs a life cycle approach to evaluate 49 common and less common solvents along with 9 deuterated solvents, across their production, laboratory use, and waste phases. Each phase is evaluated against multiple impact categories, and solvents are assigned individual impact category scores and a composite score on a scale of 1 (least favorable) to 10 (most recommended). The guide includes an in-depth discussion of solvent performance, highlighting high-impact stages, hidden costs and waste treatment strategies, among others. It also enables direct comparison of solvents within the same chemical group or with similar properties, empowering analysts to identify greener alternatives. GreenSOL is accompanied by an interactive web-based application ([ https://greensol.tuc.gr/ ]) to streamline its practical implementation. Overall, GreenSOL provides a structured, evidence-based tool to support informed decision-making and promote the adoption of greener, safer solvent alternatives in analytical chemistry. • GreenSOL evaluates the greenness of 58 solvents, including deuterated solvents • Production, Use, and Waste phases are assessed using multiple impact categories • Results highlight the importance of considering the entire lifecycle • Insights for informed decision-making in analytical chemistry labs are provided • A free-access web-based software facilitates data exploration and solvent selection