Disarming a pathogen with programmable phage-derived particles.

Siqi Yang, Brady F Cress

原始摘要（英文原文）· Original abstract

Shiga toxin-producing Escherichia coli (STEC) presents a therapeutic dilemma because antibiotic treatment induces prophage-encoded Shiga toxin expression. Galtier et al. engineer phage-derived particles with programmable cell specificity, genetic cargo, and CRISPR guide RNAs that destroy stx while killing STEC in animal models.

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