Why cell agriculture struggles with meat and opportunities for non-food tissues.

Cellular agriculture uses cells to produce animal-derived products without raising whole animals. However, scaling cultivated meat into affordable, structured food remains difficult. In this opinion, we argue that this difficulty reflects not isolated technical gaps but constraint coupling: the interdependence of tissue thickness, vascularization, cell-state stability, media cost, bioreactor scale, food safety, and consumer acceptance within the product goal of food-grade meat. We interpret recent diversification through this framework. Nonfood tissues and low-complexity cell-derived products do not eliminate these constraints but reconfigure them around product-specific requirements, including ingredient identity, material performance, durability, regulatory context, and commercial feasibility. This reframing positions diversification beyond meat as product-specific pathways with distinct constraint profiles.