Silvia Bagelova Polakova, Lubos Cipak, Juraj Gregan
Homologous recombination repairs DNA double-strand breaks by copying genetic information from an intact DNA template, but how the homologous sequence is located within the vast 3D genome remains unclear. In this forum, we discuss how cohesin, a key chromatin organizer, guides the homology search during DNA repair in mammalian cells.