Jacob Jensen, Luiza Mendonça
In this issue of Structure, Hylton et al.1 present MOSAIC, an accessible, acquisition-software-agnostic framework for montage cryo-electron tomography (cryo-ET). By streamlining acquisition and stitching workflows, MOSAIC lowers technical barriers to wide-field imaging, maximizing data recovery from cryolamellae and making meso-scale cellular architecture broadly accessible across diverse cryo-ET platforms.