Barbara Corneo, Giovanni Faga, Inês Figueira, Jacopo Zasso, Wenli Yang, Katrin Neuman, Pia A Johansson, Lyn Healy, Laurence M Daheron, Melanie Generali, Ole Pless, Ras Trokovic, Laurent David, Mehrnaz Gazhvini, Laura Batlle-Morera
Over the past three decades, advances in human pluripotent stem cell (hPSC) technologies, including induced pluripotent stem cells, gene editing, and 2D/3D models, have transformed biomedical research. These powerful tools have revolutionized disease modeling, drug discovery, and the development of advanced therapy medicinal products (ATMPs), while driving the establishment of stem cell core facilities. By providing specialized expertise, standardized workflows, and access to advanced technologies, these facilities support both fundamental and translational research, promote rigor and reproducibility, and foster collaboration. This manuscript highlights their role as hubs of excellence and discusses current challenges and future opportunities for the global stem cell community.