Beyond compensation: Organized pathological hematopoiesis in the myelofibrotic spleen.

Two studies in this issue of Cell Stem Cell show that splenic extramedullary hematopoiesis in myelofibrosis develops within a remodeled hematopoietic, immune, and stromal environment. Austin et al.1 define its cellular states, whereas Dugué et al.2 reveal the spatial and temporal remodeling of the stromal niche.