Kimberley Hemelrijk, Hugo M. Aarts, Gijs M. Broeze, Antonio Gómez Menchero, Didier Tchétché, Fabio S. de Brito, Marco Barbanti, Ran Kornowski, Azeem Latib, Augusto D’Onofrio, Flavio Ribichini, Miguel Artaiz Urdaci, Nicolas Dumonteil, Alexandre Abizaid, Samantha Sartori, Stefano Rosato, Giuseppe Tarantini, Gabriele Pesarini, Katia L. Orvin, Matteo Pagnesi, Beatriz Vaquerizo, George Dangas, Roxana Mehran, Astrid C. van Nieuwkerk, Ronak Delewi
Our study aims to investigate the clinical outcomes of patients undergoing TAVR with different types of AS.
Background: Transcatheter aortic valve replacement (TAVR) is an effective treatment in patients with "classical" concordant high-gradient aortic stenosis (AS). However, data on outcomes in patients with discordant AS are scarce. Our study aims to investigate the clinical outcomes of patients undergoing TAVR with different types of AS. Methods: The Cerebrovascular Events in Patients Undergoing Transcatheter Aortic Valve Implantation 2 (CENTER2) study is a patient-level database including 25,771 patients who underwent TAVR, of whom 15,233 were included in this analysis. Four AS subgroups were identified, and patients were classified as discordant AS (low-gradient AS with preserved or impaired left ventricular ejection fraction [LVEF] or discordant high-gradient AS) or concordant high-gradient AS. Results: = 0.04). Conclusions: Nearly 20% of patients undergoing TAVR had discordant AS. One-year mortality was higher in low-gradient AS with impaired LVEF, whereas outcomes were similar among low-gradient with preserved LVEF, discordant high-gradient, and concordant high-gradient AS.