Lab resource: single cell line generation of an induced pluripotent stem cell line UJSi006-A from a patient with ultra-treatment-resistant schizophrenia.

Ultra-treatment-resistant schizophrenia (UTRS) is the most severe subtype of treatment refractoriness, with persistent symptoms despite clozapine use. Here, we report the generation of a human induced pluripotent stem cells (iPSCs) line, UJSi006-A, derived from peripheral blood mononuclear cells (PBMCs) of a 31-year-old female patient with UTRS. The iPSC line displayed typical human pluripotent stem cell morphology, a normal karyotype, expression of pluripotency markers, and the capacity to differentiate into derivatives of all three germ layers in vitro. This iPSC resource provides a cellular platform for investigating disease mechanisms and treatment resistance in schizophrenia.